Nerve growth factor binds to normal human keratinocytes through high and low affinity receptors and stimulates their growth by a novel autocrine loop.

Di Marco, E.; Beatriz Mathor, Mônica; Bondanza, Sergio; Cutuli, Nunzio; C. Marchisio, P.; Cancedda, Ranieri; De Luca, Michele

doi:10.1016/s0021-9258(18)41604-3

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Nerve growth factor binds to normal human keratinocytes through high and low affinity receptors and stimulates their growth by a novel autocrine loop.

Shared by NobleBlocks on Oct 1, 1993 • 12:00 AM UTC

Authors:

E. Di Marco

Mônica Beatriz Mathor

Sergio Bondanza

Abstract

Normal human keratinocytes synthesize and secrete biologically active nerve growth factor (NGF) in a growth regulated fashion (Di Marco, E., Marchisio, P. C., Bondanza, S., Franzi, A. T., Cancedda, R., and De Luca, M. (1991) J. Biol. Chem. 266, 21718-21722). Here we show that the same human keratino...

Subject

Receptor

Autocrine signalling

Nerve growth factor

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