The Unfolded Protein Response Is an Important Regulator of Inflammatory Genes in Endothelial Cells

S. Gargalovic, Peter; M. Gharavi, Nima; J. Clark, Michael; Pagnon, Joanne; Yang, Wen-Pin; He, Aiqing; Truong, Amy; Baruch-Oren, Tamar; A. Berliner, Judith; G. Kirchgessner, Todd; J. Lusis, Aldons

doi:10.1161/01.atv.0000242903.41158.a1

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The Unfolded Protein Response Is an Important Regulator of Inflammatory Genes in Endothelial Cells

Shared by NobleBlocks on Nov 1, 2006 • 12:00 AM UTC

Authors:

Peter S. Gargalovic

Nima M. Gharavi

Michael J. Clark

Abstract

Objective— Oxidized 1-palmitoyl-2-arachidonyl- sn -3-glycero-phosphorylcholine (oxPAPC) accumulates in atherosclerotic lesions and in vitro studies suggest that it mediates chronic inflammatory response in endothelial cells (ECs). The goal of our studies was to identify pathways mediating the induct...

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