Region- and Type-Specific Induction of Matrix Metalloproteinases in Post–Myocardial Infarction Remodeling

Wilson, Eric; L. Moainie, Sina; M. Baskin, Julia; S. Lowry, Abigail; M. Deschamps, Anne; Mukherjee, Rupak; Sloane Guy, T.; G. St. John-Sutton, Martin; H. Gorman, Joseph; Henry Edmunds, L.; C. Gorman, Robert; G. Spinale, Francis

doi:10.1161/01.cir.0000068375.40887.fa

Public

Region- and Type-Specific Induction of Matrix Metalloproteinases in Post–Myocardial Infarction Remodeling

Published in Circulation • Jun 4, 2003

Authors:

Eric Wilson

Sina L. Moainie

Julia M. Baskin

Abstract

BACKGROUND: Induction of matrix metalloproteinases (MMPs) contributes to adverse remodeling after myocardial infarction (MI). Whether a region- and type-specific distribution of MMPs occurs within the post-MI myocardium remained unknown. METHODS AND RESULTS: Ten sheep were instrumented with a sonomi...

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Subject

Matrix metalloproteinase

Medicine

Myocardial infarction

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