Axonal Neuregulin-1 Regulates Myelin Sheath Thickness

V. Michailov, Galin; W. Sereda, Michael; G. Brinkmann, Bastian; M. Fischer, Tobias; Haug, Bernhard; Birchmeier, Carmen; Role, Lorna; Lai, Cary; H. Schwab, Markus; Nave, Klaus-Armin

doi:10.1126/science.1095862

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Axonal Neuregulin-1 Regulates Myelin Sheath Thickness

Shared by NobleBlocks on Apr 28, 2004 • 12:00 AM UTC

Authors:

Galin V. Michailov

Michael W. Sereda

Bastian G. Brinkmann

Abstract

In the nervous system of vertebrates, myelination is essential for rapid and accurate impulse conduction. Myelin thickness depends on axon fiber size. We use mutant and transgenic mouse lines to show that axonal Neuregulin-1 (Nrg1) signals information about axon size to Schwann cells. Reduced Nrg1 e...

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