Control of TRAIL-Induced Apoptosis by a Family of Signaling and Decoy Receptors

P. Sheridan, James; A. Marsters, Scot; M. Pitti, Robert; Gurney, Austin; Skubatch, Maya; Baldwin, Daryl; Ramakrishnan, Lakshmi; L. Gray, Christa; Baker, Kevin; I. Wood, William; D. Goddard, Audrey; Godowski, Paul; Ashkenazi, Avi

doi:10.1126/science.277.5327.818

Public

Control of TRAIL-Induced Apoptosis by a Family of Signaling and Decoy Receptors

Shared by NobleBlocks on Aug 8, 1997 • 12:00 AM UTC

Authors:

James P. Sheridan

Scot A. Marsters

Robert M. Pitti

Abstract

TRAIL (also called Apo2L) belongs to the tumor necrosis factor family, activates rapid apoptosis in tumor cells, and binds to the death-signaling receptor DR4. Two additional TRAIL receptors were identified. The receptor designated death receptor 5 (DR5) contained a cytoplasmic death domain and indu...

Discussions