Effect of Vericiguat, a Soluble Guanylate Cyclase Stimulator, on Natriuretic Peptide Levels in Patients With Worsening Chronic Heart Failure and Reduced Ejection Fraction: The SOCRATES-REDUCED Randomized Trial.

M, Gheorghiade; SJ, Greene; J, Butler; G, Filippatos; CS, Lam; AP, Maggioni; P, Ponikowski; SJ, Shah; SD, Solomon; E, Kraigher-Krainer; ET, Samano; K, Müller; L, Roessig; B, Pieske

doi:10.1001/jama.2015.15734

Public

Effect of Vericiguat, a Soluble Guanylate Cyclase Stimulator, on Natriuretic Peptide Levels in Patients With Worsening Chronic Heart Failure and Reduced Ejection Fraction: The SOCRATES-REDUCED Randomized Trial.

Shared by NobleBlocks on Dec 1, 2015 • 12:00 AM UTC

Authors:

Gheorghiade M

Greene SJ

Butler J

Abstract

<h4>Importance</h4>Worsening chronic heart failure (HF) is a major public health problem.<h4>Objective</h4>To determine the optimal dose and tolerability of vericiguat, a soluble guanylate cyclase stimulator, in patients with worsening chronic HF and reduced left ventricular ejection fraction (LVEF)...

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