Anti-phospholipid antibodies are directed against a complex antigen that includes a lipid-binding inhibitor of coagulation: beta 2-glycoprotein I (apolipoprotein H).

P McNeil, H; J Simpson, R; N Chesterman, C; A Krilis, S

doi:10.1073/pnas.87.11.4120

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Anti-phospholipid antibodies are directed against a complex antigen that includes a lipid-binding inhibitor of coagulation: beta 2-glycoprotein I (apolipoprotein H).

Shared by NobleBlocks on Jun 1, 1990 • 12:00 AM UTC

Authors:

H P McNeil

R J Simpson

C N Chesterman

Abstract

Anti-phospholipid (aPL) antibodies that exhibit binding in cardiolipin (CL) ELISA can be purified to greater than 95% purity by sequential phospholipid affinity and ion-exchange chromatography. However, these highly purified aPL antibodies do not bind to the CL antigen when assayed by a modified CL ...

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