Comparative genomic analysis of esophageal adenocarcinoma and squamous cell carcinoma.

N, Agrawal; Y, Jiao; C, Bettegowda; SM, Hutfless; Y, Wang; S, David; Y, Cheng; WS, Twaddell; NL, Latt; EJ, Shin; LD, Wang; L, Wang; W, Yang; VE, Velculescu; B, Vogelstein; N, Papadopoulos; KW, Kinzler; SJ, Meltzer

doi:10.1158/2159-8290.cd-12-0189

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Comparative genomic analysis of esophageal adenocarcinoma and squamous cell carcinoma.

Shared by NobleBlocks on Aug 9, 2012 • 12:00 AM UTC

Authors:

Agrawal N

Jiao Y

Bettegowda C

Abstract

Esophageal cancer ranks sixth in cancer death. To explore its genetic origins, we conducted exomic sequencing on 11 esophageal adenocarcinomas (EAC) and 12 esophageal squamous cell carcinomas (ESCC) from the United States. Interestingly, inactivating mutations of NOTCH1 were identified in 21% of ESC...

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