The Proinflammatory CD14+CD16+DR++ Monocytes Are a Major Source of TNF

Belge, Kai-Uwe; Dayyani, Farshid; Horelt, Alexia; Siedlar, Maciej; Frankenberger, Marion; Frankenberger, Bernhard; Espevik, Terje; Ziegler-Heitbrock, Löms

doi:10.4049/jimmunol.168.7.3536

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The Proinflammatory CD14+CD16+DR++ Monocytes Are a Major Source of TNF

Shared by NobleBlocks on Apr 1, 2002 • 12:00 AM UTC

Authors:

Kai-Uwe Belge

Farshid Dayyani

Alexia Horelt

Abstract

Abstract In human blood two monocyte populations can be distinguished, i.e., the CD14++CD16−DR+ classical monocytes and the CD14+CD16+DR++ proinflammatory monocytes that account for only 10% of all monocytes. We have studied TNF production in these two types of cells using three-color immunofluoresc...

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