Th17 cells and IL-17 receptor signaling are essential for mucosal host defense against oral candidiasis.

R Conti, Heather; Shen, Fang; Nayyar, Namrata; Stocum, Eileen; N Sun, Jianing; J Lindemann, Matthew; W Ho, Allen; Hoda Hai, Justine; J Yu, Jeffrey; Won Jung, Ji; G Filler, Scott; Masso-Welch, Patricia; Edgerton, Mira; L Gaffen, Sarah

doi:10.1084/jem.20081463

Public

Th17 cells and IL-17 receptor signaling are essential for mucosal host defense against oral candidiasis.

Shared by NobleBlocks on Feb 16, 2009 • 12:00 AM UTC

Authors:

Heather R Conti

Fang Shen

Namrata Nayyar

Abstract

The commensal fungus Candida albicans causes oropharyngeal candidiasis (OPC; thrush) in settings of immunodeficiency. Although disseminated, vaginal, and oral candidiasis are all caused by C. albicans species, host defense against C. albicans varies by anatomical location. T helper 1 (Th1) cells hav...

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