The stringent response of Mycobacterium tuberculosis is required for long-term survival.

TP, Primm; SJ, Andersen; V, Mizrahi; D, Avarbock; H, Rubin; CE 3rd, Barry

doi:10.1128/jb.182.17.4889-4898.2000

Public

The stringent response of Mycobacterium tuberculosis is required for long-term survival.

Shared by NobleBlocks on Sep 1, 2000 • 12:00 AM UTC

Authors:

Primm TP

Andersen SJ

Mizrahi V

Abstract

The stringent response utilizes hyperphosphorylated guanine [(p)ppGpp] as a signaling molecule to control bacterial gene expression involved in long-term survival under starvation conditions. In gram-negative bacteria, (p)ppGpp is produced by the activity of the related RelA and SpoT proteins. Mycob...

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