Complement Factor H Variant Increases the Risk of Age-Related Macular Degeneration

L. Haines, Jonathan; A. Hauser, Michael; Schmidt, Silke; K. Scott, William; M. Olson, Lana; Gallins, Paul; L. Spencer, Kylee; Ying Kwan, Shu; Noureddine, Maher; R. Gilbert, John; Schnetz-Boutaud, Nathalie; Agarwal, Anita; A. Postel, Eric; A. Pericak-Vance, Margaret

doi:10.1126/science.1110359

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Complement Factor H Variant Increases the Risk of Age-Related Macular Degeneration

Shared by NobleBlocks on Apr 15, 2005 • 12:00 AM UTC

Authors:

Jonathan L. Haines

Michael A. Hauser

Silke Schmidt

Abstract

Age-related macular degeneration (AMD) is a leading cause of visual impairment and blindness in the elderly whose etiology remains largely unknown. Previous studies identified chromosome 1q32 as harboring a susceptibility locus for AMD. We used single-nucleotide polymorphisms to interrogate this reg...

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