Matrix metalloproteinase-9: Many shades of function in cardiovascular disease.

A, Yabluchanskiy; Y, Ma; RP, Iyer; ME, Hall; ML, Lindsey

doi:10.1152/physiol.00029.2013

Public

Matrix metalloproteinase-9: Many shades of function in cardiovascular disease.

Published in Physiology (Bethesda, Md.) • Nov 1, 2013

Authors:

Yabluchanskiy A

Ma Y

Iyer RP

Abstract

Matrix metalloproteinase (MMP)-9, one of the most widely investigated MMPs, regulates pathological remodeling processes that involve inflammation and fibrosis in cardiovascular disease. MMP-9 directly degrades extracellular matrix (ECM) proteins and activates cytokines and chemokines to regulate tis...

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