Cyclophilin A Is a Damage-Associated Molecular Pattern Molecule That Mediates Acetaminophen-Induced Liver Injury

Dear, J.; Simpson, K.; Nicolai, M.; H. Catterson, J.; M. Street, Jonathan; Huizinga, T.; Craig, D.; Dhaliwal, K.; Webb, Sheila; N. Bateman, D.; Webb, D.

doi:10.4049/jimmunol.1100165

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Cyclophilin A is a damage-associated molecular pattern molecule that mediates acetaminophen-induced liver injury.

Shared by NobleBlocks on Aug 8, 2011 • 12:00 AM UTC

Authors:

Dear JW

Simpson KJ

Nicolai MP

Abstract

The immune system is alerted to cell death by molecules known as damage-associated molecular patterns (DAMPs). These molecules partly mediate acetaminophen-induced liver injury, an archetypal experimental model of sterile cell death and the commonest cause of acute liver failure in the western world...

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