CNS-PNETs with C19MC amplification and/or LIN28 expression comprise a distinct histogenetic diagnostic and therapeutic entity.

T, Spence; P, Sin-Chan; D, Picard; M, Barszczyk; K, Hoss; M, Lu; SK, Kim; YS, Ra; H, Nakamura; J, Fangusaro; E, Hwang; E, Kiehna; H, Toledano; Y, Wang; Q, Shi; D, Johnston; J, Michaud; Spina M, La; AM, Buccoliero; D, Adamek; S, Camelo-Piragua; Collins V, Peter; C, Jones; N, Kabbara; N, Jurdi; P, Varlet; A, Perry; D, Scharnhorst; X, Fan; KM, Muraszko; CG, Eberhart; HK, Ng; S, Gururangan; Meter T, Van; M, Remke; L, Lafay-Cousin; JA, Chan; N, Sirachainan; SL, Pomeroy; SC, Clifford; A, Gajjar; M, Shago; W, Halliday; MD, Taylor; R, Grundy; CC, Lau; J, Phillips; E, Bouffet; PB, Dirks; CE, Hawkins; A, Huang

doi:10.1007/s00401-014-1291-1

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CNS-PNETs with C19MC amplification and/or LIN28 expression comprise a distinct histogenetic diagnostic and therapeutic entity.

Shared by NobleBlocks on May 20, 2014 • 12:00 AM UTC

Authors:

Spence T

Sin-Chan P

Picard D

Abstract

Amplification of the C19MC oncogenic miRNA cluster and high LIN28 expression has been linked to a distinctly aggressive group of cerebral CNS-PNETs (group 1 CNS-PNETs) arising in young children. In this study, we sought to evaluate the diagnostic specificity of C19MC and LIN28, and the clinical and ...

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