Absence of putative artemisinin resistance mutations among Plasmodium falciparum in Sub-Saharan Africa: a molecular epidemiologic study.

M Taylor, Steve; M Parobek, Christian; K DeConti, Derrick; Kayentao, Kassoum; Oumar Coulibaly, Sheick; M Greenwood, Brian; Tagbor, Harry; Williams, John; Bojang, Kalifa; Njie, Fanta; Desai, Meghna; Kariuki, Simon; Gutman, Julie; P Mathanga, Don; Mårtensson, Andreas; Ngasala, Billy; D Conrad, Melissa; J Rosenthal, Philip; K Tshefu, Antoinette; M Moormann, Ann; M Vulule, John; K Doumbo, Ogobara; O Ter Kuile, Feiko; R Meshnick, Steven; A Bailey, Jeffrey; J Juliano, Jonathan

doi:10.1093/infdis/jiu467

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Absence of putative artemisinin resistance mutations among Plasmodium falciparum in Sub-Saharan Africa: a molecular epidemiologic study.

Shared by NobleBlocks on Mar 1, 2015 • 12:00 AM UTC

Authors:

Steve M Taylor

Christian M Parobek

Derrick K DeConti

Abstract

Plasmodium falciparum parasites that are resistant to artemisinins have been detected in Southeast Asia. Resistance is associated with several polymorphisms in the parasite's K13-propeller gene. The molecular epidemiology of these artemisinin resistance genotypes in African parasite populations is u...

Subject

artemisinin resistance

drug resistance

falciparum malaria

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