DNA double-strand break repair genes and oxidative damage in brain metastasis of breast cancer.

Woditschka, Stephan; Evans, Lynda; Duchnowska, Renata; Tiffany Reed, L; Palmieri, Diane; Qian, Yongzhen; Badve, Sunil; Sledge, George; Gril, Brunilde; I Aladjem, Mirit; Fu, Haiqing; M Flores, Natasha; Gökmen-Polar, Yesim; Biernat, Wojciech; Szutowicz-Zielińska, Ewa; Mandat, Tomasz; Trojanowski, Tomasz; Och, Waldemar; Czartoryska-Arlukowicz, Bogumiła; Jassem, Jacek; B Mitchell, James; S Steeg, Patricia

doi:10.1093/jnci/dju145

Public

DNA double-strand break repair genes and oxidative damage in brain metastasis of breast cancer.

Shared by NobleBlocks on Jul 1, 2014 • 12:00 AM UTC

Authors:

Stephan Woditschka

Lynda Evans

Renata Duchnowska

Abstract

BACKGROUND: Breast cancer frequently metastasizes to the brain, colonizing a neuro-inflammatory microenvironment. The molecular pathways facilitating this colonization remain poorly understood. METHODS: Expression profiling of 23 matched sets of human resected brain metastases and primary breast tum...

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