Discovery and Characterization of Alamandine

Queiroga Lautner, Roberto; C. Villela, Daniel; A. Fraga-Silva, Rodrigo; Silva, Neiva; Verano-Braga, Thiago; Costa-Fraga, Fabiana; Jankowski, Joachim; Jankowski, Vera; Sousa, Frederico; Alzamora, Andreia; Soares, Everton; Barbosa, Claudiane; Kjeldsen, Frank; Oliveira, Aline; Braga, Janaina; Savergnini, Silvia; Maia, Gisele; Bastos Peluso, Antonio; Passos-Silva, Danielle; Ferreira, Anderson; Alves, Fabiana; Martins, Almir; Raizada, Mohan; Paula, Renata; Motta-Santos, Daisy; Kemplin, Friederike; Pimenta, Adriano; Alenina, Natalia; Sinisterra, Ruben; Bader, Michael; Jose Campagnole-Santos, Maria; A.S. Santos, Robson

doi:10.1161/circresaha.113.301077

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Discovery and Characterization of Alamandine

Shared by NobleBlocks on Apr 12, 2013 • 12:00 AM UTC

Authors:

Roberto Queiroga Lautner

Daniel C. Villela

Rodrigo A. Fraga-Silva

Abstract

Rationale: The renin–angiotensin system (RAS) is a key regulator of the cardiovascular system, electrolyte, and water balance. Here, we report identification and characterization of alamandine, a new heptapeptide generated by catalytic action of angiotensin-converting enzyme-2 angiotensin A or direc...

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