Sonic hedgehog (Shh) signaling promotes tumorigenicity and stemness via activation of epithelial-to-mesenchymal transition (EMT) in bladder cancer.

SS, Islam; RB, Mokhtari; AS, Noman; M, Uddin; MZ, Rahman; MA, Azadi; A, Zlotta; der Kwast T, van; H, Yeger; WA, Farhat

doi:10.1002/mc.22300

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Sonic hedgehog (Shh) signaling promotes tumorigenicity and stemness via activation of epithelial-to-mesenchymal transition (EMT) in bladder cancer.

Shared by NobleBlocks on Mar 1, 2015 • 12:00 AM UTC

Authors:

Islam SS

Mokhtari RB

Noman AS

Abstract

Activation of the sonic hedgehog (Shh) signaling pathway controls tumorigenesis in a variety of cancers. Here, we show a role for Shh signaling in the promotion of epithelial-to-mesenchymal transition (EMT), tumorigenicity, and stemness in the bladder cancer. EMT induction was assessed by the decrea...

Subject

Bladder cancer

Emt

Shh

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