Protein kinase B kinases that mediate phosphatidylinositol 3,4,5-trisphosphate-dependent activation of protein kinase B.

L, Stephens; K, Anderson; D, Stokoe; H, Erdjument-Bromage; GF, Painter; AB, Holmes; PR, Gaffney; CB, Reese; F, McCormick; P, Tempst; J, Coadwell; PT, Hawkins

doi:10.1126/science.279.5351.710

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Protein kinase B kinases that mediate phosphatidylinositol 3,4,5-trisphosphate-dependent activation of protein kinase B.

Shared by NobleBlocks on Jan 1, 1998 • 12:00 AM UTC

Authors:

Stephens L

Anderson K

Stokoe D

Abstract

Protein kinase B (PKB) is activated in response to phosphoinositide 3-kinases and their lipid products phosphatidylinositol 3,4, 5-trisphosphate [PtdIns(3,4,5)P3] and PtdIns(3,4)P2 in the signaling pathways used by a wide variety of growth factors, antigens, and inflammatory stimuli. PKB is a direct...

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