Fc-dependent depletion of tumor-infiltrating regulatory T cells co-defines the efficacy of anti–CTLA-4 therapy against melanoma

R. Simpson, Tyler; Li, Fubin; Montalvo-Ortiz, Welby; A. Sepulveda, Manuel; Bergerhoff, Katharina; Arce, Frederick; Roddie, Claire; Y. Henry, Jake; Yagita, Hideo; D. Wolchok, Jedd; S. Peggs, Karl; V. Ravetch, Jeffrey; P. Allison, James; A. Quezada, Sergio

doi:10.1084/jem.20130579

Public

Fc-dependent depletion of tumor-infiltrating regulatory T cells co-defines the efficacy of anti–CTLA-4 therapy against melanoma

Shared by NobleBlocks on Jul 28, 2013 • 12:00 AM UTC

Authors:

Tyler R. Simpson

Fubin Li

Welby Montalvo-Ortiz

Abstract

Treatment with monoclonal antibody specific for cytotoxic T lymphocyte–associated antigen 4 (CTLA-4), an inhibitory receptor expressed by T lymphocytes, has emerged as an effective therapy for the treatment of metastatic melanoma. Although subject to debate, current models favor a mechanism of activ...

Discussions