Analysis of transcription factors key for mouse pancreatic development establishes NKX2-2 and MNX1 mutations as causes of neonatal diabetes in man.

SE, Flanagan; Franco E, De; Allen H, Lango; M, Zerah; MM, Abdul-Rasoul; JA, Edge; H, Stewart; E, Alamiri; K, Hussain; S, Wallis; Vries L, de; O, Rubio-Cabezas; JA, Houghton; EL, Edghill; AM, Patch; S, Ellard; AT, Hattersley

doi:10.1016/j.cmet.2013.11.021

Public

Analysis of transcription factors key for mouse pancreatic development establishes NKX2-2 and MNX1 mutations as causes of neonatal diabetes in man.

Shared by NobleBlocks on Jan 1, 2014 • 12:00 AM UTC

Authors:

Flanagan SE

De Franco E

Lango Allen H

Abstract

Understanding transcriptional regulation of pancreatic development is required to advance current efforts in developing beta cell replacement therapies for patients with diabetes. Current knowledge of key transcriptional regulators has predominantly come from mouse studies, with rare, naturally occu...

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