A genome-wide metabolic QTL analysis in Europeans implicates two loci shaped by recent positive selection.

Nicholson, George; Rantalainen, Mattias; V Li, Jia; D Maher, Anthony; Malmodin, Daniel; R Ahmadi, Kourosh; H Faber, Johan; Barrett, Amy; L Min, Josine; William Rayner, N; Toft, Henrik; Krestyaninova, Maria; Viksna, Juris; Guha Neogi, Sudeshna; Dumas, Marc-Emmanuel; Sarkans, Ugis; Consortium, MolPAGE; Donnelly, Peter; Illig, Thomas; Adamski, Jerzy; Suhre, Karsten; Allen, Maxine; T Zondervan, Krina; D Spector, Tim; K Nicholson, Jeremy; C Lindon, John; Baunsgaard, Dorrit; Holmes, Elaine; I McCarthy, Mark; C Holmes, Chris

doi:10.1371/journal.pgen.1002270

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A genome-wide metabolic QTL analysis in Europeans implicates two loci shaped by recent positive selection.

Shared by NobleBlocks on Sep 1, 2011 • 12:00 AM UTC

Authors:

George Nicholson

Mattias Rantalainen

Jia V Li

Abstract

We have performed a metabolite quantitative trait locus (mQTL) study of the (1)H nuclear magnetic resonance spectroscopy ((1)H NMR) metabolome in humans, building on recent targeted knowledge of genetic drivers of metabolic regulation. Urine and plasma samples were collected from two cohorts of indi...

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