Size-dependent localization and penetration of ultrasmall gold nanoparticles in cancer cells, multicellular spheroids, and tumors in vivo.

Huang, Keyang; Ma, Huili; Liu, Juan; Huo, Shuaidong; Kumar, Anil; Wei, Tuo; Zhang, Xu; Jin, Shubin; Gan, Yaling; C Wang, Paul; He, Shengtai; Zhang, Xiaoning; Liang, Xing-Jie

doi:10.1021/nn301282m

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Size-dependent localization and penetration of ultrasmall gold nanoparticles in cancer cells, multicellular spheroids, and tumors in vivo.

Shared by NobleBlocks on May 22, 2012 • 12:00 AM UTC

Authors:

Keyang Huang

Huili Ma

Juan Liu

Abstract

This work demonstrated that ultrasmall gold nanoparticles (AuNPs) smaller than 10 nm display unique advantages over nanoparticles larger than 10 nm in terms of localization to, and penetration of, breast cancer cells, multicellular tumor spheroids, and tumors in mice. Au@tiopronin nanoparticles that...

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