Activation of Transient Receptor Potential Vanilloid Type-1 Channel Prevents Adipogenesis and Obesity

Li Zhang, Li; Yan Liu, Dao; Qun Ma, Li; Dan Luo, Zhi; Bing Cao, Ting; Zhong, Jian; Cheng Yan, Zhen; Juan Wang, Li; Gang Zhao, Zhi; Jun Zhu, Shan; Schrader, Mark; Thilo, Florian; Ming Zhu, Zhi; Tepel, Martin

doi:10.1161/01.res.0000262653.84850.8b

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Activation of Transient Receptor Potential Vanilloid Type-1 Channel Prevents Adipogenesis and Obesity

Shared by NobleBlocks on Apr 13, 2007 • 12:00 AM UTC

Authors:

Li Li Zhang

Dao Yan Liu

Li Qun Ma

Abstract

We tested the hypothesis that activation of transient receptor potential vanilloid type-1 (TRPV1) by capsaicin prevents adipogenesis. TRPV1 channels in 3T3-L1-preadipocytes and visceral adipose tissue from mice and humans were detected by immunoblotting and quantitative real-time RT-PCR. The effect ...

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