Proinflammatory Activation of Macrophages by Basic Calcium Phosphate Crystals via Protein Kinase C and MAP Kinase Pathways

Nadra, Imad; C. Mason, Justin; Philippidis, Pandelis; Florey, Oliver; D.W. Smythe, Cheryl; M. McCarthy, Geraldine; C. Landis, Robert; O. Haskard, Dorian

doi:10.1161/01.res.0000171451.88616.c2

Public

Proinflammatory Activation of Macrophages by Basic Calcium Phosphate Crystals via Protein Kinase C and MAP Kinase Pathways

Shared by NobleBlocks on Jun 24, 2005 • 12:00 AM UTC

Authors:

Imad Nadra

Justin C. Mason

Pandelis Philippidis

Abstract

Basic calcium phosphate (BCP) crystal deposition underlies the development of arterial calcification. Inflammatory macrophages colocalize with BCP deposits in developing atherosclerotic lesions and in vitro can promote calcification through the release of TNF alpha. Here we have investigated whether...

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