Progressive atrophy of cerebellum and brainstem as a function of age and the size of the expanded CAG repeats in the MJD1 gene in Machado-Joseph disease.

O, Onodera; J, Idezuka; S, Igarashi; Y, Takiyama; K, Endo; H, Takano; M, Oyake; H, Tanaka; T, Inuzuka; T, Hayashi; T, Yuasa; J, Ito; T, Miyatake; S, Tsuji

doi:10.1002/ana.410430305

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Progressive atrophy of cerebellum and brainstem as a function of age and the size of the expanded CAG repeats in the MJD1 gene in Machado-Joseph disease.

Shared by NobleBlocks on Mar 1, 1998 • 12:00 AM UTC

Authors:

Onodera O

Idezuka J

Igarashi S

Abstract

Machado-Joseph disease (MJD) is an autosomal dominant neurodegenerative disease characterized by cerebellar ataxia associated to varying degrees with pyramidal signs, extrapyramidal signs, or peripheral amyotrophy. It is caused by unstable expansion of the CAG repeat in the MJD1 gene on chromosome 1...

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