Dexmedetomidine provides renoprotection against ischemia-reperfusion injury in mice.

Gu, Jianteng; Sun, Pamela; Zhao, Hailin; R Watts, Helena; D Sanders, Robert; Terrando, Niccolo; Xia, Peiyuan; Maze, Mervyn; Ma, Daqing

doi:10.1186/cc10283

Public

Dexmedetomidine provides renoprotection against ischemia-reperfusion injury in mice.

Shared by NobleBlocks on Jun 24, 2011 • 12:00 AM UTC

Authors:

Jianteng Gu

Pamela Sun

Hailin Zhao

Abstract

INTRODUCTION: Acute kidney injury following surgery incurs significant mortality with no proven preventative therapy. We investigated whether the α2 adrenoceptor agonist dexmedetomidine (Dex) provides protection against ischemia-reperfusion induced kidney injury in vitro and in vivo. METHODS: In vit...

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