A Whole-Genome Association Study of Major Determinants for Host Control of HIV-1

Fellay, Jacques; V. Shianna, Kevin; Ge, Dongliang; Colombo, Sara; Ledergerber, Bruno; Weale, Mike; Zhang, Kunlin; Gumbs, Curtis; Castagna, Antonella; Cossarizza, Andrea; Cozzi-Lepri, Alessandro; De Luca, Andrea; Easterbrook, Philippa; Francioli, Patrick; Mallal, Simon; Martinez-Picado, Javier; M. Miro, José; Obel, Niels; P. Smith, Jason; Wyniger, Josiane; Descombes, Patrick; E. Antonarakis, Stylianos; L. Letvin, Norman; J. McMichael, Andrew; F. Haynes, Barton; Telenti, Amalio; B. Goldstein, David

doi:10.1126/science.1143767

Public

A Whole-Genome Association Study of Major Determinants for Host Control of HIV-1

Shared by NobleBlocks on Aug 17, 2007 • 12:00 AM UTC

Authors:

Jacques Fellay

Kevin V. Shianna

Dongliang Ge

Abstract

Understanding why some people establish and maintain effective control of HIV-1 and others do not is a priority in the effort to develop new treatments for HIV/AIDS. Using a whole-genome association strategy, we identified polymorphisms that explain nearly 15% of the variation among individuals in v...

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