De novo identification of differentially methylated regions in the human genome

J. Peters, Timothy; Buckley, Michael; L. Statham, Aaron; Pidsley, Ruth; Samaras, Katherine; V. Lord, Reginald; J. Clark, Susan; L. Molloy, Peter

doi:10.1186/1756-8935-8-6

Public

De novo identification of differentially methylated regions in the human genome

Shared by NobleBlocks on Jan 27, 2015 • 12:00 AM UTC

Authors:

Timothy J. Peters

Michael Buckley

Aaron L. Statham

Abstract

BACKGROUND: The identification and characterisation of differentially methylated regions (DMRs) between phenotypes in the human genome is of prime interest in epigenetics. We present a novel method, DMRcate, that fits replicated methylation measurements from the Illumina HM450K BeadChip (or 450K arr...

Subject

Differentially methylated regions

Biology

Computational biology

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