Identification and Functional Characterization of Brainstem Cannabinoid CB<sub>2</sub>Receptors

D. Van Sickle, Marja; Duncan, Marnie; J. Kingsley, Philip; Mouihate, Abdeslam; Urbani, Paolo; Mackie, Ken; Stella, Nephi; Makriyannis, Alexandros; Piomelli, Daniele; S. Davison, Joseph; J. Marnett, Lawrence; Di Marzo, Vincenzo; J. Pittman, Quentin; D. Patel, Kamala; A. Sharkey, Keith

doi:10.1126/science.1115740

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Identification and Functional Characterization of Brainstem Cannabinoid CB<sub>2</sub>Receptors

Shared by NobleBlocks on Oct 14, 2005 • 12:00 AM UTC

Authors:

Marja D. Van Sickle

Marnie Duncan

Philip J. Kingsley

Abstract

The presence and function of CB 2 receptors in central nervous system (CNS) neurons are controversial. We report the expression of CB 2 receptor messenger RNA and protein localization on brainstem neurons. These functional CB 2 receptors in the brainstem were activated by a CB 2 receptor agonist, 2-...

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