Validated LC-MS/MS methods for the determination of dapagliflozin, a sodium-glucose co-transporter 2 inhibitor in normal and ZDF rat plasma.

AF, Aubry; H, Gu; R, Magnier; L, Morgan; X, Xu; M, Tirmenstein; B, Wang; Y, Deng; J, Cai; P, Couerbe; M, Arnold

doi:10.4155/bio.10.139

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Validated LC-MS/MS methods for the determination of dapagliflozin, a sodium-glucose co-transporter 2 inhibitor in normal and ZDF rat plasma.

Shared by NobleBlocks on Dec 1, 2010 • 12:00 AM UTC

Authors:

Aubry AF

Gu H

Magnier R

Abstract

<h4>Background</h4>Dapagliflozin is an inhibitor of sodium-glucose co-transporter 2 (SGLT-2) in development for the treatment of Type 2 diabetes. To support toxicology studies, LC-MS/MS methods were developed and validated for the quantitation of dapagliflozin in rat plasma.<h4>Results</h4>The assay...

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