A novel in vivo model of tau propagation with rapid and progressive neurofibrillary tangle pathology: the pattern of spread is determined by connectivity, not proximity

Ahmed, Zeshan; Cooper, Jane; K. Murray, Tracey; Garn, Katya; McNaughton, Emily; Clarke, Hannah; Parhizkar, Samira; A. Ward, Mark; Cavallini, Annalisa; Jackson, Samuel; Bose, Suchira; Clavaguera, Florence; Tolnay, Markus; Lavenir, Isabelle; Goedert, Michel; L. Hutton, Michael; J. O’Neill, Michael

doi:10.1007/s00401-014-1254-6

Public

A novel in vivo model of tau propagation with rapid and progressive neurofibrillary tangle pathology: the pattern of spread is determined by connectivity, not proximity

Shared by NobleBlocks on Feb 16, 2014 • 12:00 AM UTC

Authors:

Zeshan Ahmed

Jane Cooper

Tracey K. Murray

Abstract

Abstract Intracellular inclusions composed of hyperphosphorylated filamentous tau are a hallmark of Alzheimer’s disease, progressive supranuclear palsy, Pick’s disease and other sporadic neurodegenerative tauopathies. Recent in vitro and in vivo studies have shown that tau aggregates do not only see...

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