Global phylogeny of Mycobacterium tuberculosis based on single nucleotide polymorphism (SNP) analysis: insights into tuberculosis evolution, phylogenetic accuracy of other DNA fingerprinting systems, and recommendations for a minimal standard SNP set.

I, Filliol; AS, Motiwala; M, Cavatore; W, Qi; MH, Hazbón; del Valle M, Bobadilla; J, Fyfe; L, García-García; N, Rastogi; C, Sola; T, Zozio; MI, Guerrero; CI, León; J, Crabtree; S, Angiuoli; KD, Eisenach; R, Durmaz; ML, Joloba; A, Rendón; J, Sifuentes-Osornio; de León A, Ponce; MD, Cave; R, Fleischmann; TS, Whittam; D, Alland

doi:10.1128/jb.188.2.759-772.2006

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Global phylogeny of Mycobacterium tuberculosis based on single nucleotide polymorphism (SNP) analysis: insights into tuberculosis evolution, phylogenetic accuracy of other DNA fingerprinting systems, and recommendations for a minimal standard SNP set.

Shared by NobleBlocks on Jan 1, 2006 • 12:00 AM UTC

Authors:

Filliol I

Motiwala AS

Cavatore M

Abstract

We analyzed a global collection of Mycobacterium tuberculosis strains using 212 single nucleotide polymorphism (SNP) markers. SNP nucleotide diversity was high (average across all SNPs, 0.19), and 96% of the SNP locus pairs were in complete linkage disequilibrium. Cluster analyses identified six dee...

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