Targeting tumor metabolism with 2‐deoxyglucose in patients with castrate‐resistant prostate cancer and advanced malignancies

N. Stein, Mark; Lin, Hongxia; Jeyamohan, Chandrika; Dvorzhinski, Dmitri; Gounder, Murugesan; Bray, Kevin; Eddy, Simantini; Goodin, Susan; White, Eileen; S. DiPaola, Robert

doi:10.1002/pros.21172

Public

Targeting tumor metabolism with 2‐deoxyglucose in patients with castrate‐resistant prostate cancer and advanced malignancies

Published in The Prostate • Apr 29, 2010

Authors:

Mark N. Stein

Hongxia Lin

Chandrika Jeyamohan

Abstract

BACKGROUND: A profound difference between cancer and normal tissues is the preferential utilization of glycolysis by cancer cells. To translate this paradigm in the clinic, we completed a phase I study of 2-deoxyglucose (2DG), and assessed 2DG uptake with fluorodeoxyglucose (FDG) positron emission t...

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Open Access

Subject

Medicine

Prostate cancer

Fluorodeoxyglucose

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