Common genetic variants highlight the role of insulin resistance and body fat distribution in type 2 diabetes, independent of obesity.

RA, Scott; T, Fall; D, Pasko; A, Barker; SJ, Sharp; L, Arriola; B, Balkau; A, Barricarte; I, Barroso; H, Boeing; F, Clavel-Chapelon; FL, Crowe; JM, Dekker; G, Fagherazzi; E, Ferrannini; NG, Forouhi; PW, Franks; D, Gavrila; V, Giedraitis; S, Grioni; LC, Groop; R, Kaaks; TJ, Key; T, Kühn; LA, Lotta; PM, Nilsson; K, Overvad; D, Palli; S, Panico; JR, Quirós; O, Rolandsson; N, Roswall; C, Sacerdote; N, Sala; MJ, Sánchez; MB, Schulze; A, Siddiq; N, Slimani; I, Sluijs; AM, Spijkerman; A, Tjonneland; R, Tumino; der A DL, van; H, Yaghootkar; MI, McCarthy; RK, Semple; E, Riboli; M, Walker; E, Ingelsson; TM, Frayling; DB, Savage; C, Langenberg; NJ, Wareham

doi:10.2337/db14-0319

Public

Common genetic variants highlight the role of insulin resistance and body fat distribution in type 2 diabetes, independent of obesity.

Shared by NobleBlocks on Jun 19, 2014 • 12:00 AM UTC

Authors:

Scott RA

Fall T

Pasko D

Abstract

We aimed to validate genetic variants as instruments for insulin resistance and secretion, to characterize their association with intermediate phenotypes, and to investigate their role in type 2 diabetes (T2D) risk among normal-weight, overweight, and obese individuals. We investigated the associati...

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