Induction of Dickkopf-1, a negative modulator of the Wnt pathway, is associated with neuronal degeneration in Alzheimer's brain.

A, Caricasole; A, Copani; F, Caraci; E, Aronica; AJ, Rozemuller; A, Caruso; M, Storto; G, Gaviraghi; GC, Terstappen; F, Nicoletti; F, Nicoletti

doi:10.1523/jneurosci.1381-04.2004

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Induction of Dickkopf-1, a negative modulator of the Wnt pathway, is associated with neuronal degeneration in Alzheimer's brain.

Published in The Journal of neuroscience : the official journal of the Society for Neuroscience • Jun 1, 2004

Authors:

Caricasole A

Copani A

Caraci F

Abstract

We used primary cultures of cortical neurons to examine the relationship between beta-amyloid toxicity and hyperphosphorylation of the tau protein, the biochemical substrate for neurofibrillary tangles of Alzheimer's brain. Exposure of the cultures to beta-amyloid peptide (betaAP) induced the expres...

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