Mesenchymal glioma stem cells are maintained by activated glycolytic metabolism involving aldehyde dehydrogenase 1A3.

P, Mao; K, Joshi; J, Li; SH, Kim; P, Li; L, Santana-Santos; S, Luthra; UR, Chandran; PV, Benos; L, Smith; M, Wang; B, Hu; SY, Cheng; RW, Sobol; I, Nakano

doi:10.1073/pnas.1221478110

Public

Mesenchymal glioma stem cells are maintained by activated glycolytic metabolism involving aldehyde dehydrogenase 1A3.

Shared by NobleBlocks on May 6, 2013 • 12:00 AM UTC

Authors:

Mao P

Joshi K

Li J

Abstract

Tumor heterogeneity of high-grade glioma (HGG) is recognized by four clinically relevant subtypes based on core gene signatures. However, molecular signaling in glioma stem cells (GSCs) in individual HGG subtypes is poorly characterized. Here we identified and characterized two mutually exclusive GS...

Subject

Glioblastoma

Glioblastoma Multiforme

Cancer Stem Cell

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