Protease‐activated receptor 2 sensitizes the transient receptor potential vanilloid 4 ion channel to cause mechanical hyperalgesia in mice

D. Grant, Andrew; S. Cottrell, Graeme; Amadesi, Silvia; Trevisani, Marcello; Nicoletti, Paola; Materazzi, Serena; Altier, Christophe; Cenac, Nicolas; W. Zamponi, Gerald; Bautista‐Cruz, Francisco; Barajas Lopez, Carlos; K. Joseph, Elizabeth; D. Levine, Jon; Liedtke, Wolfgang; Vanner, Stephen; Vergnolle, Nathalie; Geppetti, Pierangelo; W. Bunnett, Nigel

doi:10.1113/jphysiol.2006.121111

Public

Protease‐activated receptor 2 sensitizes the transient receptor potential vanilloid 4 ion channel to cause mechanical hyperalgesia in mice

Shared by NobleBlocks on Jan 26, 2007 • 12:00 AM UTC

Authors:

Andrew D. Grant

Graeme S. Cottrell

Silvia Amadesi

Abstract

Exacerbated sensitivity to mechanical stimuli that are normally innocuous or mildly painful (mechanical allodynia and hyperalgesia) occurs during inflammation and underlies painful diseases. Proteases that are generated during inflammation and disease cleave protease‐activated receptor 2 (PAR 2 ) on...

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