Distinct cytokine profiles of systemic-onset juvenile idiopathic arthritis-associated macrophage activation syndrome with particular emphasis on the role of interleukin-18 in its pathogenesis.

M, Shimizu; T, Yokoyama; K, Yamada; H, Kaneda; H, Wada; T, Wada; T, Toma; K, Ohta; Y, Kasahara; A, Yachie

doi:10.1093/rheumatology/keq133

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Distinct cytokine profiles of systemic-onset juvenile idiopathic arthritis-associated macrophage activation syndrome with particular emphasis on the role of interleukin-18 in its pathogenesis.

Shared by NobleBlocks on May 14, 2010 • 12:00 AM UTC

Authors:

Shimizu M

Yokoyama T

Yamada K

Abstract

<h4>Objectives</h4>To compare the pro-inflammatory cytokine profiles and the cytokine kinetics in patients with secondary macrophage activation syndrome (MAS) due to systemic-onset juvenile idiopathic arthritis (s-JIA) and in both active and inactive disease states of s-JIA (but no MAS), with those ...

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