Gut CD103+ dendritic cells express indoleamine 2,3-dioxygenase which influences T regulatory/T effector cell balance and oral tolerance induction.

G, Matteoli; E, Mazzini; ID, Iliev; E, Mileti; F, Fallarino; P, Puccetti; M, Chieppa; M, Rescigno

doi:10.1136/gut.2009.185108

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Gut CD103+ dendritic cells express indoleamine 2,3-dioxygenase which influences T regulatory/T effector cell balance and oral tolerance induction.

Shared by NobleBlocks on May 1, 2010 • 12:00 AM UTC

Authors:

Matteoli G

Mazzini E

Iliev ID

Abstract

<h4>Objective</h4>CD103(+) gut dendritic cells (DCs) have been shown to be required for de novo conversion of adaptive T regulatory (Treg) cells. Indoleamine 2,3-dioxygenase (IDO) is an enzyme involved in tryptophan catabolism that is expressed by DCs isolated from tumour-draining lymph nodes. IDO-e...

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