The effects of genetic polymorphisms of CYP2C9 and CYP2C19 on phenytoin metabolism in Japanese adult patients with epilepsy: studies in stereoselective hydroxylation and population pharmacokinetics.

K, Mamiya; I, Ieiri; J, Shimamoto; E, Yukawa; J, Imai; H, Ninomiya; H, Yamada; K, Otsubo; S, Higuchi; N, Tashiro

doi:10.1111/j.1528-1157.1998.tb01330.x

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The effects of genetic polymorphisms of CYP2C9 and CYP2C19 on phenytoin metabolism in Japanese adult patients with epilepsy: studies in stereoselective hydroxylation and population pharmacokinetics.

Shared by NobleBlocks on Dec 1, 1998 • 12:00 AM UTC

Authors:

Mamiya K

Ieiri I

Shimamoto J

Abstract

<h4>Purpose</h4>The aim of this study was to clarify the effects of genetic polymorphisms of cytochrome P450 (CYP) 2C9 and 2C19 on the metabolism of phenytoin (PHT). In addition, a population pharmacokinetic analysis was performed.<h4>Methods</h4>The genotype of CYP2C9 (Arg144/Cys, Ile359/Leu) and C...

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