Human constitutive androstane receptor (CAR) and pregnane X receptor (PXR) support the hypertrophic but not the hyperplastic response to the murine nongenotoxic hepatocarcinogens phenobarbital and chlordane in vivo.

J, Ross; SM, Plummer; A, Rode; N, Scheer; CC, Bower; O, Vogel; CJ, Henderson; CR, Wolf; CR, Elcombe

doi:10.1093/toxsci/kfq118

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Human constitutive androstane receptor (CAR) and pregnane X receptor (PXR) support the hypertrophic but not the hyperplastic response to the murine nongenotoxic hepatocarcinogens phenobarbital and chlordane in vivo.

Shared by NobleBlocks on Apr 19, 2010 • 12:00 AM UTC

Authors:

Ross J

Plummer SM

Rode A

Abstract

Mouse nongenotoxic hepatocarcinogens phenobarbital (PB) and chlordane induce hepatomegaly characterized by hypertrophy and hyperplasia. Increased cell proliferation is implicated in the mechanism of tumor induction. The relevance of these tumors to human health is unclear. The xenoreceptors, constit...

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