Serial Analysis of Gene Expression Identifies Metallothionein-II as Major Neuroprotective Gene in Mouse Focal Cerebral Ischemia

Trendelenburg, George; Prass, Konstantin; Priller, Josef; Kapinya, Krisztian; Polley, Andreas; Muselmann, Claudia; Ruscher, Karsten; Kannbley, Ute; O. Schmitt, Armin; Castell, Stefanie; Wiegand, Frank; Meisel, Andreas; Rosenthal, André; Dirnagl, Ulrich

doi:10.1523/jneurosci.22-14-05879.2002

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Serial Analysis of Gene Expression Identifies Metallothionein-II as Major Neuroprotective Gene in Mouse Focal Cerebral Ischemia

Shared by NobleBlocks on Jul 15, 2002 • 12:00 AM UTC

Authors:

George Trendelenburg

Konstantin Prass

Josef Priller

Abstract

We applied serial analysis of gene expression (SAGE) to study differentially expressed genes in mouse brain 14 hr after the induction of focal cerebral ischemia. Analysis of >60,000 transcripts revealed 83 upregulated and 94 downregulated transcripts (more than or equal to eightfold). Reproducibilit...

Subject

Downregulation and upregulation

Metallothionein

Neuroprotection

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