The mgrB gene as a key target for acquired resistance to colistin in Klebsiella pneumoniae.

Poirel, Laurent; Jayol, Aurélie; Bontron, Séverine; Villegas, Maria-Virginia; Ozdamar, Melda; Türkoglu, Salih; Nordmann, Patrice

doi:10.1093/jac/dku323

Public

The mgrB gene as a key target for acquired resistance to colistin in Klebsiella pneumoniae.

Shared by NobleBlocks on Jan 1, 2015 • 12:00 AM UTC

Authors:

Laurent Poirel

Aurélie Jayol

Séverine Bontron

Abstract

OBJECTIVES: Alterations in the PhoPQ two-component regulatory system may be associated with colistin resistance in Klebsiella pneumoniae. MgrB is a small transmembrane protein produced upon activation of the PhoPQ signalling system, and acts as a negative regulator on this system. We investigated th...

Subject

Klebsiella pneumoniae

PhoPQ regulatory system

gene inactivation

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