Randomized comparison of gemcitabine, dexamethasone, and cisplatin versus dexamethasone, cytarabine, and cisplatin chemotherapy before autologous stem-cell transplantation for relapsed and refractory aggressive lymphomas: NCIC-CTG LY.12.

M, Crump; J, Kuruvilla; S, Couban; DA, MacDonald; V, Kukreti; CT, Kouroukis; M, Rubinger; R, Buckstein; KR, Imrie; M, Federico; Renzo N, Di; K, Howson-Jan; T, Baetz; L, Kaizer; M, Voralia; HJ, Olney; AR, Turner; J, Sussman; AE, Hay; MS, Djurfeldt; RM, Meyer; BE, Chen; LE, Shepherd

doi:10.1200/jco.2013.53.9593

Public

Randomized comparison of gemcitabine, dexamethasone, and cisplatin versus dexamethasone, cytarabine, and cisplatin chemotherapy before autologous stem-cell transplantation for relapsed and refractory aggressive lymphomas: NCIC-CTG LY.12.

Shared by NobleBlocks on Sep 29, 2014 • 12:00 AM UTC

Authors:

Crump M

Kuruvilla J

Couban S

Abstract

<h4>Purpose</h4>For patients with relapsed or refractory aggressive lymphoma, we hypothesized that gemcitabine-based therapy before autologous stem-cell transplantation (ASCT) is as effective as and less toxic than standard treatment.<h4>Patients and methods</h4>We randomly assigned 619 patients wit...

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