High-dose ursodeoxycholic acid for the treatment of primary sclerosing cholangitis.

D Lindor, Keith; V Kowdley, Kris; A C Luketic, Velimir; Edwyn Harrison, M; McCashland, Timothy; S Befeler, Alex; Harnois, Denise; Jorgensen, Roberta; Petz, Jan; Keach, Jill; Mooney, Jody; Sargeant, Carol; Braaten, Julie; Bernard, Tamara; King, Debra; Miceli, Ellen; Schmoll, Jeff; Hoskin, Tanya; Thapa, Prabin; Enders, Felicity

doi:10.1002/hep.23082

Public

High-dose ursodeoxycholic acid for the treatment of primary sclerosing cholangitis.

Shared by NobleBlocks on Sep 1, 2009 • 12:00 AM UTC

Authors:

Keith D Lindor

Kris V Kowdley

Velimir A C Luketic

Abstract

Previous controlled trials are inconclusive regarding the efficacy of ursodeoxycholic acid (UDCA) for treating primary sclerosing cholangitis (PSC). One hundred fifty adult patients with PSC were enrolled in a long-term, randomized, double-blind controlled trial of high-dose UDCA (28-30 mg/kg/day) v...

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