DNA hypermethylation of promoter of gene p53 and p16 in arsenic-exposed people with and without malignancy.

S, Chanda; UB, Dasgupta; D, Guhamazumder; M, Gupta; U, Chaudhuri; S, Lahiri; S, Das; N, Ghosh; D, Chatterjee

doi:10.1093/toxsci/kfj030

Public

DNA hypermethylation of promoter of gene p53 and p16 in arsenic-exposed people with and without malignancy.

Shared by NobleBlocks on Oct 26, 2005 • 12:00 AM UTC

Authors:

Chanda S

Dasgupta UB

Guhamazumder D

Abstract

Chronic arsenic exposure is known to produce arsenicosis and cancer. To ascertain whether perturbation of methylation plays a role in such carcinogenesis, the degree of methylation of p53 and p16 gene in DNA obtained from blood samples of people chronically exposed to arsenic and skin cancer subject...

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