Human sperm devoid of PLC, zeta 1 fail to induce Ca(2+) release and are unable to initiate the first step of embryo development.

Yoon, Sook-Young; Jellerette, Teru; Maria Salicioni, Ana; Chang Lee, Hoi; Yoo, Myung-Sik; Coward, Kevin; Parrington, John; Grow, Daniel; B Cibelli, Jose; E Visconti, Pablo; Mager, Jesse; A Fissore, Rafael

doi:10.1172/jci36942

Public

Human sperm devoid of PLC, zeta 1 fail to induce Ca(2+) release and are unable to initiate the first step of embryo development.

Shared by NobleBlocks on Nov 1, 2008 • 12:00 AM UTC

Authors:

Sook-Young Yoon

Teru Jellerette

Ana Maria Salicioni

Abstract

Egg activation, which is the first step in the initiation of embryo development, involves both completion of meiosis and progression into mitotic cycles. In mammals, the fertilizing sperm delivers the activating signal, which consists of oscillations in free cytosolic Ca(2+) concentration ([Ca(2+)](...

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