Neutrophils Activate Plasmacytoid Dendritic Cells by Releasing Self-DNA–Peptide Complexes in Systemic Lupus Erythematosus

Lande, Roberto; Ganguly, Dipyaman; Facchinetti, Valeria; Frasca, Loredana; Conrad, Curdin; Gregorio, Josh; Meller, Stephan; Chamilos, Georgios; Sebasigari, Rosalie; Riccieri, Valeria; Bassett, Roland; Amuro, Hideki; Fukuhara, Shirou; Ito, Tomoki; Liu, Yong-Jun; Gilliet, Michel

doi:10.1126/scitranslmed.3001180

Public

Neutrophils Activate Plasmacytoid Dendritic Cells by Releasing Self-DNA–Peptide Complexes in Systemic Lupus Erythematosus

Shared by NobleBlocks on Mar 9, 2011 • 12:00 AM UTC

Authors:

Roberto Lande

Dipyaman Ganguly

Valeria Facchinetti

Abstract

In systemic lupus erythematosus, neutrophils release peptide/self-DNA complexes that trigger plasmacytoid dendritic cell activation and autoantibody formation.

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